A closer look at neurodegenerative diseases

Neurodegenerative diseases are disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous system.

Dementia and Alzheimer’s disease

Facts and Figures

Brain changes

Diagnosis

Disease management

Dementia causes symptoms that affect memory, thinking, and social abilities severely enough to interfere with a patient’s daily life.



Podcast episode

How can technology slow the global rise of neurodegenerative diseases? (1/3) | Healthcare Perspectives
23
How can technology slow the global rise of neurodegenerative diseases? (1/3) | Healthcare Perspectives
0:000:00
0:00
Learn about the current methods of detecting neurodegenerative diseases and what they involve. You’ll also hear about the important role that wearable devices are playing in the field of brain health. Additionally, you’ll learn about what the medical profession is doing to prepare for an increase in the number of patients.

Jun Hatazawa, MD, PhD, currently serves as chief executive director of the Japan Radioisotope Association


Andreas Papadopoulos

Visualization of the hippocampal sub-structures in the patient’s brain is possible with ultra-high-field magnetic resonance imaging. 0,2 mm in-plane resolution offers potential for clinical evaluation in patients with Alzheimer‘s disease.
Increased image contrast and high resolution enable the identification of small anatomical structures and the clear differentiation between gray, white matter and cerebrospinal fluid.

Podcast episode

How can we spot the early signs of dementia? (2/3) | Healthcare Perspectives
26
How can we spot the early signs of dementia? (2/3) | Healthcare Perspectives
0:000:00
0:00
Hear about the options that are currently available in the detection of Alzheimer's disease. You’ll also learn about the use of Biomarkers in monitoring the disease’s progression and how that information can be used in managing it. Lastly, you’ll hear about the ongoing Alzheimer's research and the questions they are seeking answers for.

Parkinson‘s Disease

Facts and Figures

Brain changes

Diagnosis

Disease management

Parkinson signs and symptoms can be different for every patient. Early signs might be mild and can even go unnoticed.

Computer illustration showing healthy substantia nigra and degenerated substantia nigra in the human brain.

Hiroshi Matsuda, MD, PhD, is the current director of the Cyclotron and Drug Discovery Research Center at the Southern Tohoku Research Institute for Neuroscience.

A normal SPECT DaT image (top) with the corresponding MR image (bottom).

A normal SPECT DaT image (top) with the corresponding MR image (bottom). While DaT imaging is normally done with SPECT/CT, the striatum is better localized on MR images.

Proton MR spectroscopy at 7 Tesla2 can be used to provide not only metabolic information, but also anatomical information. Ultra-high resolution spectroscopy has potential for clinical applications such as in tumors, epilepsy, multiple sclerosis and other neurodegenerative diseases.

DBS

Multiple Sclerosis

Facts and Figures

Brain changes

Diagnosis

Disease management

Multiple sclerosis is a disease with unpredictable symptoms that can also vary in intensity. Different symptoms can manifest during relapses or attacks.

Siemens Healthineers Press Pictures

Standard FLAIR together with SHI at 7T may help better understanding multiple sclerosis. Detecting iron accumulation and the vein densitiy in plaques can be possible thanks to ultra-high resolution at 7T.

How to accelerate progress in diagnosis and treatment

3 

Given the limited diagnostic and therapeutic options for neurodegenerative diseases, researchers, and industry are pooling their strengths.

Podcast episode

No two patients are alike: How can AI monitor neurodegenerative diseases? (3/3) | Healthcare Perspectives
23
No two patients are alike: How can AI monitor neurodegenerative diseases? (3/3) | Healthcare Perspectives
0:000:00
0:00
Stay tuned to learn about why it is difficult to predict how a neurodegenerative disease will progress in one patient based on data collected from other patients. You’ll also learn about the importance of data sharing among the groups doing research. Lastly, you’ll hear about the role that AI is playing in creating models that can be used in the detection, treatment, and monitoring of patients.

What lies ahead?

Looking at the near future - what could be possible next steps and developments?


Adriana Maggi researched on the role of estrogen in neurodegenerative diseases.

Medicines in development for neurodegenerative diseases